透明质酸钠对SD大鼠致畸敏感期的毒性试验

doi:10.3969/j.issn.1004-616x.2011.05.014

›› 2011, Vol. 23 ›› Issue (5): 380-383.doi: 10.3969/j.issn.1004-616x.2011.05.014

透明质酸钠对SD大鼠致畸敏感期的毒性试验

彭亮,傅伟忠,王彦武,覃辉艳,姚思宇,梁慧莉,何励

广西自治区疾病预防控制中心，广西南宁 530028

收稿日期:2011-02-14 修回日期:2011-05-03 出版日期:2011-09-30 发布日期:2011-09-30
通讯作者: 彭亮

Study of the sodium hyaluronate toxicity on SD rats in sensitive period of teratogenesis

PENG Liang，FU Wei-zhong，WANG Yan-wu，QIN Hui-yan，YAO Si-yu，LIANG Hui-li，HE Li

Guangxi Autonomous Regional Center for Disease Control and Prevention, Nanning 530028 Guangxi, China

Received:2011-02-14 Revised:2011-05-03 Online:2011-09-30 Published:2011-09-30
Contact: PENG Liang

摘要/Abstract

摘要： 目的：探讨透明质酸钠对SD大鼠致畸敏感期的毒性。方法：将妊娠期SD大鼠随机分为5个组，分别为3个透明质酸钠不同剂量试验组 (1 333、667和333 mg/kg)、阴性对照组 (去离子水)和阳性对照组 (250 mg/kg阿司匹林)，每组不少于12只。在大鼠致畸敏感期 (妊娠第7～16天)，连续经口灌胃给予受试物10 d，每天1次。妊娠第20天处死孕鼠，取出胎鼠，检测胚胎和胎仔发育指标，并检查外观、内脏和骨骼有无畸形。结果：透明质酸钠各剂量组孕鼠体质量、子宫连胎质量、活胎率、死胎率，胎鼠体质量、身长和尾长与阴性对照组相比较，差异均无统计学意义(P＞0.05)，也未见外观、内脏和骨骼畸形。结论：透明质酸钠在本试验剂量下，对SD大鼠无母体毒性和致畸毒性。

关键词: 透明质酸钠, SD大鼠, 致畸毒性

Abstract: OBJECTIVE: To explore the toxicity of sodium hyaluronate on SD rats in sensitive period of teratogenesis. METHODS：Pregnant rats were divided randomly into five groups，three sodium hyaluronate groups (1 333， 667 and 333 mg/kg)，one negative control given deionized water，and one positive control given Aspirin (250 mg/kg). There were at least 12 pregnant rats in each group. During the sensitive period of teratogenesis (the 7th to 16th day of gestation)，the pregnant rats of each group were given test sample orally once a day for ten days. On the 20th day of gestation，the pregnant rats were sacrificed. Embryonic and fetal development were evaluated，appearance，viscesal and skeletal abnormalities were observed. RESULTS：In sodium hyaluronate groups，the weight of pregnant rats and uterus including fetuses，living fetus rate，dead fetus rate，body weight，length of body and tail of fetuses were not significantly different from negative control. No abnormality of skeleton，organ and body was identified in fetuses of groups treated with sodium hyaluronate. CONCLUSION：At dosages used in this study，sodium hyaluronate had neither maternal toxicity nor teratogenecity in pregnant SD rats.

Key words: sodium hyaluronate, SD rats, teratogenecity

彭亮,傅伟忠,王彦武,覃辉艳,姚思宇,梁慧莉,何励. 透明质酸钠对SD大鼠致畸敏感期的毒性试验[J]. , 2011, 23(5): 380-383.

PENG Liang，FU Wei-zhong，WANG Yan-wu，QIN Hui-yan，YAO Si-yu，LIANG Hui-li，HE Li. Study of the sodium hyaluronate toxicity on SD rats in sensitive period of teratogenesis[J]. , 2011, 23(5): 380-383.

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透明质酸钠对SD大鼠致畸敏感期的毒性试验

Study of the sodium hyaluronate toxicity on SD rats in sensitive period of teratogenesis

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